Sunday, December 02, 2018

An evidence-based approach to pinpoint genotoxicity in the River Danube

In this study we combined bioassays, chemical analysis, and QSAR modelling to identify genotoxic contaminants in the surface water samples from the River Danube. We started with a screening for the three most bioactive samples using the fish embryo toxicity test (FET). Thereafter we tested for genotoxicity by means of the Ames fluctuation and the micronucleus assays. The chemicals found in the samples after non-target analysis (different study) were then filtered for the genotoxicants based on QSAR modelling and literature data. An artificial mixture of all these potential genotoxicants was tested in Ames and micronucleus, and we could explain nearly 50 % of the genotoxicity with 18 of the substances found in the samples.

Find out more about "Integrating bioassays, chemical analysis and in silico techniques to identify genotoxicants in surface water" (fulltext only with a subscription to the journal, sorry...)

Saturday, December 01, 2018

On their way to becoming scientists, students can have fun with science theories

It is certainly a good idea to expose students to the principles, concepts, and challenges of science theories before they ente the world of independent research during their first job or PhD thesis. Unfortunately, this is a rather hard, dry topic. Science theories stem from philosophy, which is in my point of view primarily one thing: incomprehensibly complicated, while offering some of the best solutions to the worlds biggest problems - quite useless, when a negligible part of society understands them.

And so are science theories. They all deliver some really good thoughts, buried in a pile of endless sentences filled with all kind of technical terms in a usage of language that is definitely not meant for non-philosophers. When in addition science theories are not part of the curriculum (bad enough), and hence a class on these concepts is voluntary for the students, you end up with the only option: to offer an evening course.

Science theories for interested students after regular classes, after an already exhausting eight-hour-day in lectures, seminars, practicals?! Can this attract, let alone excite students? Well, seems I found a way in my new skill course „Students Running Scientific“.

In this advanced skill course running every summer semester science theories are the background of everything. We start with an introduction, a bit of recap of the winter course "Students Going Scientific", and some additional thoughts on the Münchhausen trilemma. This enters already the world of scientific theories, since this thought experiment is about proving the final truth. The trilemma knows three possible ways how to eventually fail - and one will always fail:

  1. infinite regress
  2. circular argument
  3. termination.

To illustrate the infinite regress I use an "infinite painting" (guy holds a painting of a guy holding a painting of a guy...). This helps to understand the fact that there's no final proof in science - only 99.9+ empircal evidence. To depict the circular argument the "Hole in the bucket" by Harry Belafonte (actually, it originates from a German folk song) is really helpful. Henry had it all thought through already, when his lady still believes the problem could be solved. This eventually leads to the termination, which is nicely represented by M.C. Escher's painting "Ascending and Descending".

At the end of this first unit the students get to pick their topic for the next two units from a wide range of different scientific theories, where these theories are introduced and explained in 10-minute presentations. However, there's a catch: everyone will give the presentation of someone else, which is known as "PowerPoint karaoke". The students are challenged to prepare their slides in a way that any other course member would be able to present and thus understand them. This way preparing, giving and hearing presentations on scientific theories is not only great fun, but tremendously helps the students to experience what the audience would be able to catch from their presentation. It is a means to step outside their own head and take a look at their topic from an external perspective. Long texts are definitely not working well, but meaningful images with few words do a pretty good job. Rings a bell? This is a key concept in "presentationzen", which I introduce in the other skill course. And here we learn why presentations with too much text greatly fail.

In unit 3 we have the presentations again, but this time each student gives their own one. Only, every thirty seconds someone in the audience shows a sign with an emotion on it, like "aggressive", "happy", "sad". Presenters have to continue their talk for the next thirty seconds with expressing that emotion. The emotion changes every minute, so there's always thirty seconds inbetween without any imposed emotion. This is a nice exercise to be more expressive in presentations. People really need to start acting. They would never do that (well, most wouldn't) without being "forced" to, but it gains them a great deal of very valuable experience. It can also help to manage spontaneous emotions when giving a talk. I coined this approach "sudden mood swings".

By surviving these two units students have withstand their ordeal by fire: giving a presentation they never saw before on a topic they don't know in an uncontrollable state of mind. Anything thereafter in their career is easier than this. And what should I say: so far all of them were doing great. It certainly is the challenge they face, which takes them to new levels.

For the next unit, each student has to prepare a role in the science communcation chain. They get randomly assigned one of these: Journalist, Newspaper Editor, Press Officer, News Agency Editor, Tabloid Editor, Blogger. The students should have an idea about the specific language their role uses, the aims and goals in communication, the target audience, typical desires, interests, concerns and maybe fears.

The unit starts with an insight into the most relevant concepts of scientific writing. We practice "one sentence, one fact", "implicit wording", and "active language" by optimising short key statements on a selection of science theories. Thereafter, we feed short news pieces on another selection of science theories into certain communication chains. Such a chain can, e.g., start with a press release from a press officer, picked up by a journalist, and finaly edited and published by a newspaper editor. Or a blogger writes about something interesting, this is picked up by a newspaper editor and finally covered by a tabloid editor. After running several news through a large variety of communication chains we read out the different steps and results and discuss what happened - and why. In this unit we learn how news from science can be altered, generalised, and also misused based on the specific culture in different news outlets. It is hands-on experience, and also some fun.

Finally, in the last unit I present the students my own good and bad examples of poster design, in chronological order, to show them how I developed over the years. We intensely discuss the do's and don'ts, the continuous improvement, and further ideas for a really good poster. Then, the students are tasked in several groups to design their own poster based on what they just worked out as best practice. The topics are one last time science theories. Each group can pick the topic they want to present. It is maybe astonishing: they all can do really nice posters (far better than my first tries) in less than three hours.

Students leave the course with a deep understanding of the basic concepts of science theories, a good idea about slides design that takes the audience into account, the confidence that they can master any situation when giving a talk, some basic knowledge in scientific writing and poster design, and a fundamental understanding of the difficulties to get ones key message through a given communication chain. And once more they took a step towards becoming scientists.


Thursday, September 06, 2018

Scientists should defend democracy...and aren't we all scientists?

I am not going to make a political statement here. Democracy in general, the principles behind, the benefits and difficulties of having a majority-driven decision process, and the sacrifices we all have to accept to make democracy a working concept, are beyond politics. They are beyond beliefs and opinions, beyond political directions and parties...and ideologies.

However, for democracy to work that way and being able to resist attacks from undemocratic sources (whatever they are and whereever they come from), everyone participating in democratic processes needs be able to make well-informed decisions. It's not what we believe that should lead us in democracy, its the facts. Its not our opinions that should steer us towards a certain decision, its the facts. It's not our political home or party that should motivate us to have our say on a given topic, it's the facts. And it's by far not ideology that should control how we shape the future of our societies - but the facts.

Facts are what we initially perceive as the truth after stripping off all misunderstandings and misinterpretations. Facts is what remains after we took a scientific look at what we first saw, heard, felt, and thus, believed. A scientific look. A look that questions what we perceive, that takes different perspectives and includes views from different angles. A look that challenges our intial, shallow treatment of what we readily understand as the truth. A look that provides enough scepticism to let common sense shine through and help avoiding traps.

This is how scientists work. They have a hypothesis, a certain belief. Then they design experiments to test that hypothesis. Of course, since it is their belief in the first place, the experimental design is biased. You cannot design an experiment without an expected outcome. By means of the experiments scientists generate data. And these they interprete. They ask the data against the background of all the knowledge available so far: what are you telling me? Their interpretation has to stand against everything that is known about the specific topic, and it has to fit in this knowledge to advance it. Or it has to disprove the current knowledge with sufficient evidence, which is - of course - also backed by a body of other knowledge where the findings fit into.

Working scientifically means to not take a first impression as the truth, but to dig deep into any issue, until finding the core of it. This core is the fact to build an opinion that leads to a belief. While scientists are rather good at this exercise in the laboratory or whereever they work, today's world could use quite a bit scientific thinking outside the ivory tower.

Currently, nearly any political debate in any country seems loaded with more non-scientific or even pseudo-scientific reasoning then maybe ever before in history. Statements and claims are just made, with no evidence given, no proof provided, no proper arguments presented.

When the president of the United States tweets that everybody thinks he is doing a great job and that no president before him accomplished as much as he did so far, where's the scientists asking who "everybody" is, whether he refers to the world, the USA, Washington, the White House? Where's the scientists demanding proof in the form of polls, quotes - facts? People might see this as trivial, believing that everybody should know it is nonsense. But a significant fraction of the American people believe this. If it remains unchallenged, it seems sort of proven. Otherwise people who know better would speak out, wouldn't they?!

When in Chemnitz, Germany, thousands of extrem right-wing, antimuslimic, racist and neo-Nazi people together with the AfD party protest against a homicide allegedly committed by refugees, because the victim was - at least partly - German, and the state premier of Saxony, Michael Kretschmer, downplays this as only a harmless commemoration march, where's the scientists pointing out that in 2017 405 persons were murdered, without thousands of people taking to the streets? Where's the scientists challenging Kretschmer in asking what he believes why strangers from all over the republic suddenly feel compelled to mourn about this dead young man? Where's the scientists asking why the extrem right-wing care about a German-Cuban? That person wouldn't be at all Aryan in their perfect world.

We scientists were trained to think in a particular way and the taxpayer mostly covered the costs for this training. We are meant to form the intellectual spearhead of society, finding and presenting the truth about any scientific question. But we should also find, present and ultimatively protect any truth; by providing the facts, collected through scientific thinking. We are the "elite" that the society has to rely on. If we scientists do not reveal the facts behind any political statement, development or initiative, who does?!

Democracy only works if people can make well-informed decisions. We scientists can make sure that the facts become clearly visible. However, it's then on the people to look at the facts, understand them and draw their conclusion. This requires also the ability for scientific thinking. Only when people understand, why a given fact is the truth, and not so what they initially perceived, they can also accept the fact as the basis of their decision making.

Scientific thinking is not a superpower. It is a specific strategy for looking at putative knowledge and find the shortcomings of the first impression of it - in case there are any. It requires training, because people need to get used to it. Besides this it relies mainly on an open mind, a good portion of scepticism and self-awarenss, and common sense. Hence, we need scientific education already at the early ages.

Consequently, everybody can be a scientist - or better - a scientific thinker. And everybody should be. Not only to be able to better understand and rate the facts scientists had hopefully dug out, but to be able by themselves to strip off all misleading information from the "truth" they get presented. To get to the facts, make well-informed decisions, and make democracy work.

Friday, March 02, 2018

All the honour money can‘t buy

At our university we have an award for exceptional engagement in teaching and education. This is good, and shows how RWTH values teaching as an essential task for a university.

Last year I applied for this award, called „RWTH Lecturer“. It is endowed with 7.500 Euro. The title „RWTH Lecturer“ also permits to officially supervise BSc and MSc thesis. And most importantly, it recognises the quality of the teaching the laureates do. It shows appreciation by the university for the job one does as a lecturer. 

The reviewers had the following to say about my work:
  • High to exceptionally high personal engagement and autonomy in teaching with diverse independent teaching concepts.
  • Broad experience and high diversity in teaching, highly motivated in education, exceptional university teaching, with very good evaluation by the students.
  • High publication record.
  • High acquisition of third party funding.
They came to the conclusion that my performance is just not enough for the award. And the reason seems to be that the budget for the award is too limited to recognise me. They had to decide about funding. 

Now, that‘s interesting! I get no recognition for my teaching activities, because of a lack of money?! In reverse, is good education only possible with additional costs?

The „Students going/running scientific“ courses cost only one thing: my free time, since I give them in the evening, clearly after my working day, and I cannot compensate for overtime. I and my family pay for this teaching. No prize money could change that.

The lecture I give on the bioavailability and bioaccumulation of contaminants with the example of chocolate during Christmas time only requires a bag of chocolate sweets. I am happy to pay this privately. Besides this, all it takes is a strong dedication to a teaching that helps the students better anchoring knowledge to memorable examples.

The time I spent to advise students in terms of mobility, going abroad, studying a semester in a foreign country, and the time it costs to coordinate the various mobility programmes, cannot be reimbursed using money. We also couldn't purchase anything that would reduce effort in this regards.

The dedication to quality teaching in lectures, seminars, and practicals, is nothing that one could buy. It also wouldn‘t help to involve a student asssistant from some prize money in whatever tasks, to free up time for improving my teaching material. All I do on a daily basis can be done only be me. We have our resources optimised in this way.

By the way, in terms of improvement, didn‘t some important people say that my teaching is already exceptional? I do not blame the reviewers. They were urged to take a decision. I blame the idea behind attaching funding to a recognition of exceptional teaching.

Telling someone they are doing a good job costs nothing but some kind words. It became so rare in our world. Everything has to be connected to money. But on the contrary, showing appreciation for personal engagement and dedication satisfies and motivates, thus increasing productivity. If you like you can put a price tag on that.

I will apply for the RWTH Lecturer again this year, if allowed. And I might be awarded, if only few candidates are better rated, albeit nothing significant has changed since 2017. It would be only because there‘s funding available. This is the part that really demotivates me.